Call Me Cecilia is story about a high school ladies' man who messes with the wrong girl. In the course of courting his new conquest at a party, Cecil accidentally falls on top of her in a drunken state. In an angry response, the girl, Beth, uses her special powers and puts a spell on Cecil, effectively sending him into a parallel world where he has to be a female for a full year. Over the course of that period, Cecil, now called Cecilia, gradually transforms from the boy he was into the girl he is to become. He must adjust to the many male and female differences and make sense of who he is while living out his female life. Over the course of time, Cecilia endures the horrible pain of a breakup and losing a lifelong friend. At the end of the spell, Cecilia must then decide whether to remain a girl or go back to being the boy he was before his transformation.